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mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
Growth factors and nutrients enhance protein synthesis and suppress overall protein degradation by activating the protein kinase mammalian target of rapamycin (mTOR). Conversely, nutrient or serum deprivation inhibits mTOR and stimulates protein breakdown by inducing autophagy, which provides the st...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703015/ https://ncbi.nlm.nih.gov/pubmed/26669439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521919112 |
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