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Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR
BACKGROUND: In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and autophagy...
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| Publicado no: | Cell Commun Signal |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6498594/ https://ncbi.nlm.nih.gov/pubmed/31046771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0354-2 |
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