High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth

Neuroblastoma is a malignant extracranial solid tumor arising from the sympathoadrenal lineage of the neural crest and is often associated with <i>N-MYC</i> amplification. Cathepsin D has been associated with chemoresistance in N-MYC-overexpressing neuroblastomas. Increased EGFR expressi...

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Main Authors: Eleonora Secomandi, Amreen Salwa, Chiara Vidoni, Alessandra Ferraresi, Carlo Follo, Ciro Isidoro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:International Journal of Molecular Sciences
Assuntos:
cancer
lysosomes
prognosis
cell cycle
EGF
growth factor
Acesso em linha:https://www.mdpi.com/1422-0067/23/9/4782
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