MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors

Lysosomal degradation of ubiquitinated β(2)-adrenergic receptors (β(2)ARs) serves as a major mechanism of long-term desensitization in response to prolonged agonist stimulation. Surprisingly, the βAR antagonist carvedilol also induced ubiquitination and lysosomal trafficking of both endogenously exp...

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Hlavní autoři: Han, Sang-oh, Xiao, Kunhong, Kim, Jihee, Wu, Jiao-Hui, Wisler, James W., Nakamura, Nobuhiro, Freedman, Neil J., Shenoy, Sudha K.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514787/
https://ncbi.nlm.nih.gov/pubmed/23166351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201208192
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