HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load

Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by t...

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Detalhes bibliográficos
Main Authors: Rousseau, Christine M., Daniels, Marcus G., Carlson, Jonathan M., Kadie, Carl, Crawford, Hayley, Prendergast, Andrew, Matthews, Philippa, Payne, Rebecca, Rolland, Morgane, Raugi, Dana N., Maust, Brandon S., Learn, Gerald H., Nickle, David C., Coovadia, Hoosen, Ndung'u, Thumbi, Frahm, Nicole, Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Bhattacharya, Tanmoy, Heckerman, David E., Korber, Bette T., Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447109/
https://ncbi.nlm.nih.gov/pubmed/18434400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02455-07
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