Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

BACKGROUND: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolut...

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Main Authors: Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen, Ndung'u, Thumbi, Goulder, Philip J. R., Walker, Bruce D., Brander, Christian, Heckerman, David E., Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931691/
https://ncbi.nlm.nih.gov/pubmed/20824187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012463
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