Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics

BACKGROUND: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (AA) co-variation. To characterize the interplay between Cytotoxic T Lymphocyte (CTL)-mediated pressure and HIV-1 evolut...

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Bibliografische gegevens
Hoofdauteurs: Rolland, Morgane, Carlson, Jonathan M., Manocheewa, Siriphan, Swain, J. Victor, Lanxon-Cookson, Erinn, Deng, Wenjie, Rousseau, Christine M., Raugi, Dana N., Learn, Gerald H., Maust, Brandon S., Coovadia, Hoosen, Ndung'u, Thumbi, Goulder, Philip J. R., Walker, Bruce D., Brander, Christian, Heckerman, David E., Mullins, James I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2010
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931691/
https://ncbi.nlm.nih.gov/pubmed/20824187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012463
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