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Fitness Costs of Mutations at the HIV-1 Capsid Hexamerization Interface

The recently available x-ray crystal structure of HIV-1 capsid hexamers has provided insight into the molecular interactions crucial for the virus’s mature capsid formation. Amino acid changes at these interaction points are likely to have a strong impact on capsid functionality and, hence, viral in...

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Detalhes bibliográficos
Main Authors: Manocheewa, Siriphan, Swain, J. Victor, Lanxon-Cookson, Erinn, Rolland, Morgane, Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681919/
https://ncbi.nlm.nih.gov/pubmed/23785468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066065
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