HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity

To overcome the problem of HIV-1 variability, candidate vaccine antigens have been designed to be composed of conserved elements of the HIV-1 proteome. Such candidate vaccines could be improved with a better understanding of both HIV-1 evolutionary constraints and the fitness cost of specific mutati...

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Main Authors: Rolland, Morgane, Manocheewa, Siriphan, Swain, J. Victor, Lanxon-Cookson, Erinn C., Kim, Moon, Westfall, Dylan H., Larsen, Brendan B., Gilbert, Peter B., Mullins, James I.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
主題:
Genetic Diversity and Evolution
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648173/
https://ncbi.nlm.nih.gov/pubmed/23468488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03033-12
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