HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load

Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by t...

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Autori principali: Rousseau, Christine M., Daniels, Marcus G., Carlson, Jonathan M., Kadie, Carl, Crawford, Hayley, Prendergast, Andrew, Matthews, Philippa, Payne, Rebecca, Rolland, Morgane, Raugi, Dana N., Maust, Brandon S., Learn, Gerald H., Nickle, David C., Coovadia, Hoosen, Ndung'u, Thumbi, Frahm, Nicole, Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Bhattacharya, Tanmoy, Heckerman, David E., Korber, Bette T., Mullins, James I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447109/
https://ncbi.nlm.nih.gov/pubmed/18434400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02455-07
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