HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load

Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by t...

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Główni autorzy: Rousseau, Christine M., Daniels, Marcus G., Carlson, Jonathan M., Kadie, Carl, Crawford, Hayley, Prendergast, Andrew, Matthews, Philippa, Payne, Rebecca, Rolland, Morgane, Raugi, Dana N., Maust, Brandon S., Learn, Gerald H., Nickle, David C., Coovadia, Hoosen, Ndung'u, Thumbi, Frahm, Nicole, Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Bhattacharya, Tanmoy, Heckerman, David E., Korber, Bette T., Mullins, James I.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology (ASM) 2008
Hasła przedmiotowe:
Pathogenesis and Immunity
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447109/
https://ncbi.nlm.nih.gov/pubmed/18434400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02455-07
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