HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load

Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by t...

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Main Authors: Rousseau, Christine M., Daniels, Marcus G., Carlson, Jonathan M., Kadie, Carl, Crawford, Hayley, Prendergast, Andrew, Matthews, Philippa, Payne, Rebecca, Rolland, Morgane, Raugi, Dana N., Maust, Brandon S., Learn, Gerald H., Nickle, David C., Coovadia, Hoosen, Ndung'u, Thumbi, Frahm, Nicole, Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Bhattacharya, Tanmoy, Heckerman, David E., Korber, Bette T., Mullins, James I.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
主題:
Pathogenesis and Immunity
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447109/
https://ncbi.nlm.nih.gov/pubmed/18434400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02455-07
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