Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point

Much uncertainty still exists over what T-cell responses need to be induced by an effective human immunodeficiency virus (HIV) vaccine. Previous studies have hypothesized that the effective CD8(+) T-cell responses are those driving the selection of escape mutations that reduce viral fitness and ther...

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Autori principali: Matthews, Philippa C., Prendergast, Andrew, Leslie, Alasdair, Crawford, Hayley, Payne, Rebecca, Rousseau, Christine, Rolland, Morgane, Honeyborne, Isobella, Carlson, Jonathan, Kadie, Carl, Brander, Christian, Bishop, Karen, Mlotshwa, Nonkululeko, Mullins, James I., Coovadia, Hoosen, Ndung'u, Thumbi, Walker, Bruce D., Heckerman, David, Goulder, Philip J. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519667/
https://ncbi.nlm.nih.gov/pubmed/18596105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00580-08
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