Rare HLA Drive Additional HIV Evolution Compared to More Frequent Alleles

HIV-1 can evolve HLA-specific escape variants in response to HLA-mediated cellular immunity. HLA alleles that are common in the host population may increase the frequency of such escape variants at the population level. When loss of viral fitness is caused by immune escape variation, these variants...

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Detalhes bibliográficos
Main Authors: Rousseau, Christine M., Lockhart, David W., Listgarten, Jennifer, Maley, Stephen N., Kadie, Carl, Learn, Gerald H., Nickle, David C., Heckerman, David E., Deng, Wenjie, Brander, Christian, Ndung'u, Thumbi, Coovadia, Hoosen, Goulder, Philip J.R., Korber, Bette T., Walker, Bruce D., Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693345/
https://ncbi.nlm.nih.gov/pubmed/19327049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2008.0208
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