HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load

Human immunodeficiency virus type 1 (HIV-1) mutations that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These mutations can then revert upon transmission to a new host in the absence of CTL-mediated immune selection pressure restricted by t...

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Main Authors: Rousseau, Christine M., Daniels, Marcus G., Carlson, Jonathan M., Kadie, Carl, Crawford, Hayley, Prendergast, Andrew, Matthews, Philippa, Payne, Rebecca, Rolland, Morgane, Raugi, Dana N., Maust, Brandon S., Learn, Gerald H., Nickle, David C., Coovadia, Hoosen, Ndung'u, Thumbi, Frahm, Nicole, Brander, Christian, Walker, Bruce D., Goulder, Philip J. R., Bhattacharya, Tanmoy, Heckerman, David E., Korber, Bette T., Mullins, James I.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
Pathogenesis and Immunity
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447109/
https://ncbi.nlm.nih.gov/pubmed/18434400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02455-07
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