Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface

The off-rate (k(off)) of the T cell receptor (TCR)/peptide-major histocompatibility complex class I (pMHCI) interaction, and hence its half-life, is the principal kinetic feature that determines the biological outcome of TCR ligation. However, it is unclear whether the CD8 coreceptor, which binds pM...

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Autores principales: Wooldridge, Linda, van den Berg, Hugo A., Glick, Meir, Gostick, Emma, Laugel, Bruno, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David A., Sewell, Andrew K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441837/
https://ncbi.nlm.nih.gov/pubmed/15837791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M500555200
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