Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

CD8(+) cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement. The CD8 c...

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Detalhes bibliográficos
Main Authors: Wooldridge, Linda, Lissina, Anna, Vernazza, Jonathan, Gostick, Emma, Laugel, Bruno, Hutchinson, Sarah L, Mirza, Fareed, Dunbar, P Rod, Boulter, Jonathan M, Glick, Meir, Cerundolo, Vincenzo, van den Berg, Hugo A, Price, David A, Sewell, Andrew K
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2007
Assuntos:
Immunomodulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699427/
https://ncbi.nlm.nih.gov/pubmed/17429845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200636765
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