Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I molecules are currently being used in cancer patients to elicit stronger T cell responses. However, it remains unclear as to how alterations of anchor residues may affect T cell receptor (TCR) recognition. We...

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Main Authors: Chen, Ji-Li, Stewart-Jones, Guillaume, Bossi, Giovanna, Lissin, Nikolai M., Wooldridge, Linda, Choi, Ed Man Lik, Held, Gerhard, Dunbar, P. Rod, Esnouf, Robert M., Sami, Malkit, Boulter, Jonathan M., Rizkallah, Pierre, Renner, Christoph, Sewell, Andrew, van der Merwe, P. Anton, Jakobsen, Bent K., Griffiths, Gillian, Jones, E. Yvonne, Cerundolo, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213140/
https://ncbi.nlm.nih.gov/pubmed/15837811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042323
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