Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

The mammalian α/β T cell receptor (TCR) repertoire plays a pivotal role in adaptive immunity by recognizing short, processed, peptide antigens bound in the context of a highly diverse family of cell-surface major histocompatibility complexes (pMHCs). Despite the extensive TCR–MHC interaction surface...

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Hlavní autoři: Dunn, Steven M., Rizkallah, Pierre J., Baston, Emma, Mahon, Tara, Cameron, Brian, Moysey, Ruth, Gao, Feng, Sami, Malkit, Boulter, Jonathan, Li, Yi, Jakobsen, Bent K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242494/
https://ncbi.nlm.nih.gov/pubmed/16600963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051936406
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