Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface

The off-rate (k(off)) of the T cell receptor (TCR)/peptide-major histocompatibility complex class I (pMHCI) interaction, and hence its half-life, is the principal kinetic feature that determines the biological outcome of TCR ligation. However, it is unclear whether the CD8 coreceptor, which binds pM...

Full description

Saved in:
Bibliographic Details
Main Authors: Wooldridge, Linda, van den Berg, Hugo A., Glick, Meir, Gostick, Emma, Laugel, Bruno, Hutchinson, Sarah L., Milicic, Anita, Brenchley, Jason M., Douek, Daniel C., Price, David A., Sewell, Andrew K.
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441837/
https://ncbi.nlm.nih.gov/pubmed/15837791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M500555200
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items