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Generation of Antiviral Major Histocompatibility Complex Class I-Restricted T Cells in the Absence of CD8 Coreceptors

The CD8 coreceptor is important for positive selection of major histocompatibility complex I (MHC-I)-restricted thymocytes and in the generation of pathogen-specific T cells. However, the requirement for CD8 in these processes may not be essential. We previously showed that mice lacking β(2)-microgl...

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Bibliographic Details
Main Authors: Andrews, Nicolas P., Pack, Christopher D., Lukacher, Aron E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346753/
https://ncbi.nlm.nih.gov/pubmed/18337581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02698-07
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