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Coreceptor CD8-driven modulation of T cell antigen receptor specificity
The CD8 coreceptor modulates the interaction between the T cell antigen receptor (TCR) and peptide-major histocompatibility class I (pMHCI). We present evidence that CD8 not only modifies the affinity of cognate TCR/pMHCI binding by altering both the association rate and the dissociation rate of the...
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| Publicado en: | J Theor Biol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6485485/ https://ncbi.nlm.nih.gov/pubmed/17869274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2007.08.002 |
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