Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the α3 domain. Second, it is able to accommodate unusually long peptides as a result of peptide ‘kinking’ in the binding groove. Third, CD8(+) cytotoxic T lymphocyte...

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Bibliographische Detailangaben
Hauptverfasser: Gostick, Emma, Cole, David K, Hutchinson, Sarah L, Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno, Lissina, Anna, Oxenius, Annette, Boulter, Jonathan M, Price, David A, Sewell, Andrew K
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2007
Schlagworte:
Molecular immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699040/
https://ncbi.nlm.nih.gov/pubmed/17273992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200636243
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