Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the α3 domain. Second, it is able to accommodate unusually long peptides as a result of peptide ‘kinking’ in the binding groove. Third, CD8(+) cytotoxic T lymphocyte...

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Detalhes bibliográficos
Main Authors: Gostick, Emma, Cole, David K, Hutchinson, Sarah L, Wooldridge, Linda, Tafuro, Sabrina, Laugel, Bruno, Lissina, Anna, Oxenius, Annette, Boulter, Jonathan M, Price, David A, Sewell, Andrew K
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2007
Assuntos:
Molecular immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699040/
https://ncbi.nlm.nih.gov/pubmed/17273992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200636243
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