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Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
HLA-A*6801 exhibits several unusual features. First, it is known to bind weakly to CD8 due to the presence of an A245V substitution in the α3 domain. Second, it is able to accommodate unusually long peptides as a result of peptide ‘kinking’ in the binding groove. Third, CD8(+) cytotoxic T lymphocyte...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
WILEY-VCH Verlag
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699040/ https://ncbi.nlm.nih.gov/pubmed/17273992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200636243 |
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