Cellular-Level Versus Receptor-Level Response Threshold Hierarchies in T-Cell Activation

Peptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others. This threshold hierarchy could reside at the receptor level, where different response pathways branch off at differe...

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Main Authors: van den Berg, Hugo A., Ladell, Kristin, Miners, Kelly, Laugel, Bruno, Llewellyn-Lacey, Sian, Clement, Mathew, Cole, David K., Gostick, Emma, Wooldridge, Linda, Sewell, Andrew K., Bridgeman, John S., Price, David A.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2013
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763380/
https://ncbi.nlm.nih.gov/pubmed/24046768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00250
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