Vaccine-Stimulated, Adoptively Transferred CD8(+) T Cells Traffic Indiscriminately and Ubiquitously while Mediating Specific Tumor Destruction

It has been suggested that antitumor T cells specifically traffic to the tumor site, where they effect tumor destruction. To test whether tumor-reactive CD8(+) T cells specifically home to tumor, we assessed the trafficking of gp100-specific pmel-1 cells to large, vascularized tumors that express or...

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Main Authors: Palmer, Douglas C., Balasubramaniam, Sanjeeve, Hanada, Ken-ichi, Wrzesinski, Claudia, Yu, Zhiya, Farid, Shahram, Theoret, Marc R., Hwang, Leroy N., Klebanoff, Christopher A., Gattinoni, Luca, Goldstein, Allan L., Yang, James C., Restifo, Nicholas P.
Format: Artigo
Language:Inglês
Published: 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241746/
https://ncbi.nlm.nih.gov/pubmed/15585842
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