Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8(+) T cells

Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve the antitumor efficacy of transferred CD8(+) T cells, but the specific mechanisms that contribute to this enhanced immunity remain poorly defined. Elimination of CD4(+)CD25(+) regulatory T (T reg) cells has bee...

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Bibliografski detalji
Glavni autori: Gattinoni, Luca, Finkelstein, Steven E., Klebanoff, Christopher A., Antony, Paul A., Palmer, Douglas C., Spiess, Paul J., Hwang, Leroy N., Yu, Zhiya, Wrzesinski, Claudia, Heimann, David M., Surh, Charles D., Rosenberg, Steven A., Restifo, Nicholas P.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Brief Definitive Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1397916/
https://ncbi.nlm.nih.gov/pubmed/16203864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050732
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