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Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

Lymphodepletion followed by adoptive cell transfer (ACT) of autologous, tumor-reactive T cells boosts antitumor immunotherapeutic activity in mouse and in humans. In the most recent clinical trials, lymphodepletion together with ACT has an objective response rate of 50% in patients with solid metast...

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Main Authors: Klebanoff, Christopher A, Khong, Hung T, Antony, Paul A, Palmer, Douglas C, Restifo, Nicholas P
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1388277/
https://ncbi.nlm.nih.gov/pubmed/15668127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2004.12.003
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