Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

Until recently, the degradation of aberrant and unassembled proteins retained in the endoplasmic reticulum (ER) was thought to involve unidentified ER-localized proteases. We now show that the ER-associated degradation (ERAD) of two mutant proteins that accumulate in the ER lumen is inhibited in a p...

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Bibliographic Details
Main Authors: Werner, Eric D., Brodsky, Jeffrey L., McCracken, Ardythe A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1996
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC19430/
https://ncbi.nlm.nih.gov/pubmed/8943015
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