Mutant Fibrinogen Cleared from the Endoplasmic Reticulum via Endoplasmic Reticulum-Associated Protein Degradation and Autophagy : An Explanation for Liver Disease

The endoplasmic reticulum (ER) quality control processes recognize and remove aberrant proteins from the secretory pathway. Several variants of the plasma protein fibrinogen are recognized as aberrant and degraded by ER-associated protein degradation (ERAD), thus leading to hypofibrinogenemia. A sub...

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Bibliografiska uppgifter
Huvudupphovsmän: Kruse, Kristina B., Dear, Amy, Kaltenbrun, Erin R., Crum, Brandan E., George, Peter M., Brennan, Stephen O., McCracken, Ardythe A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2006
Ämnen:
Original Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606570/
https://ncbi.nlm.nih.gov/pubmed/16565503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051097
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