Mutant Fibrinogen Cleared from the Endoplasmic Reticulum via Endoplasmic Reticulum-Associated Protein Degradation and Autophagy : An Explanation for Liver Disease

The endoplasmic reticulum (ER) quality control processes recognize and remove aberrant proteins from the secretory pathway. Several variants of the plasma protein fibrinogen are recognized as aberrant and degraded by ER-associated protein degradation (ERAD), thus leading to hypofibrinogenemia. A sub...

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Detalhes bibliográficos
Main Authors: Kruse, Kristina B., Dear, Amy, Kaltenbrun, Erin R., Crum, Brandan E., George, Peter M., Brennan, Stephen O., McCracken, Ardythe A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606570/
https://ncbi.nlm.nih.gov/pubmed/16565503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051097
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