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Mutant Fibrinogen Cleared from the Endoplasmic Reticulum via Endoplasmic Reticulum-Associated Protein Degradation and Autophagy : An Explanation for Liver Disease

The endoplasmic reticulum (ER) quality control processes recognize and remove aberrant proteins from the secretory pathway. Several variants of the plasma protein fibrinogen are recognized as aberrant and degraded by ER-associated protein degradation (ERAD), thus leading to hypofibrinogenemia. A sub...

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Detaylı Bibliyografya
Asıl Yazarlar: Kruse, Kristina B., Dear, Amy, Kaltenbrun, Erin R., Crum, Brandan E., George, Peter M., Brennan, Stephen O., McCracken, Ardythe A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606570/
https://ncbi.nlm.nih.gov/pubmed/16565503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051097
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