Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

Until recently, the degradation of aberrant and unassembled proteins retained in the endoplasmic reticulum (ER) was thought to involve unidentified ER-localized proteases. We now show that the ER-associated degradation (ERAD) of two mutant proteins that accumulate in the ER lumen is inhibited in a p...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Werner, Eric D., Brodsky, Jeffrey L., McCracken, Ardythe A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19430/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943015/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13797
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