Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation

Macrophages that are recruited to the site of implanted biomaterials undergo fusion to form surface-damaging foreign body giant cells. Exposure of peripheral blood monocytes to interleukin-4 can recapitulate the fusion process in vitro. In this study, we used interleukin-4 to induce multinucleation...

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Autores principales: Jay, Steven M., Skokos, Eleni, Laiwalla, Farah, Krady, Marie-Marthe, Kyriakides, Themis R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2007
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934537/
https://ncbi.nlm.nih.gov/pubmed/17556592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.061213
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