Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow

The role of Rac family proteins in platelet spreading on matrix proteins under static and flow conditions has been investigated by using Rac-deficient platelets. Murine platelets form filopodia and undergo limited spreading on fibrinogen independent of Rac1 and Rac2. In the presence of thrombin, mar...

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Main Authors: McCarty, Owen J. T., Larson, Mark K., Auger, Jocelyn M., Kalia, Neena, Atkinson, Ben T., Pearce, Andrew C., Ruf, Sandra, Henderson, Robert B., Tybulewicz, Victor L. J., Machesky, Laura M., Watson, Steve P.
Format: Artigo
Jezik:Inglês
Izdano: 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395485/
https://ncbi.nlm.nih.gov/pubmed/16195235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M504672200
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