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Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation

Macrophages that are recruited to the site of implanted biomaterials undergo fusion to form surface-damaging foreign body giant cells. Exposure of peripheral blood monocytes to interleukin-4 can recapitulate the fusion process in vitro. In this study, we used interleukin-4 to induce multinucleation...

詳細記述

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書誌詳細
主要な著者: Jay, Steven M., Skokos, Eleni, Laiwalla, Farah, Krady, Marie-Marthe, Kyriakides, Themis R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Investigative Pathology 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934537/
https://ncbi.nlm.nih.gov/pubmed/17556592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.061213
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