Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

We tested the effects of small-molecule XIAP antagonists based on a polyphenylurea pharmacophore on cultured acute myelogenous leukemia (AML) cell lines and primary patient samples. X-linked inhibitor of apoptosis protein (XIAP) antagonist N-[(5R)-6-[(anilinocarbonyl)amino]-5-((anilinocarbonyl){[(2R...

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Autores principales: Carter, Bing Z., Gronda, Marcela, Wang, Zhiliang, Welsh, Kate, Pinilla, Clemencia, Andreeff, Michael, Schober, Wendy D., Nefzi, Adel, Pond, Gregory R., Mawji, Imtiaz A., Houghten, Richard A., Ostresh, John, Brandwein, Joseph, Minden, Mark D., Schuh, Andre C., Wells, Richard A., Messner, Hans, Chun, Kathy, Reed, John C., Schimmer, Aaron D.
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2005 by The American Society of Hematology 2005
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895077/
https://ncbi.nlm.nih.gov/pubmed/15687241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3168
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