Small-molecule XIAP antagonist restores caspase-9–mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

Clinical outcome in patients with primary nodal diffuse large B-cell lymphomas (DLBCLs) is correlated with expression of inhibitors of the intrinsic apoptosis pathway, including X-linked inhibitor of apoptosis protein (XIAP). XIAP suppresses apoptosis through inhibiting active caspase-3, caspase-7,...

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Detalhes bibliográficos
Main Authors: Cillessen, Saskia A. G. M., Reed, John C., Welsh, Kate, Pinilla, Clemencia, Houghten, Richard, Hooijberg, Erik, Deurhof, José, Castricum, Kitty C. M., Kortman, Pim, Hess, Corine J., Ossenkoppele, Gert J., Meijer, Chris J. L. M., Oudejans, Joost J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200818/
https://ncbi.nlm.nih.gov/pubmed/17916749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-085480
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