Small-molecule XIAP antagonist restores caspase-9–mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

Clinical outcome in patients with primary nodal diffuse large B-cell lymphomas (DLBCLs) is correlated with expression of inhibitors of the intrinsic apoptosis pathway, including X-linked inhibitor of apoptosis protein (XIAP). XIAP suppresses apoptosis through inhibiting active caspase-3, caspase-7,...

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Autori principali: Cillessen, Saskia A. G. M., Reed, John C., Welsh, Kate, Pinilla, Clemencia, Houghten, Richard, Hooijberg, Erik, Deurhof, José, Castricum, Kitty C. M., Kortman, Pim, Hess, Corine J., Ossenkoppele, Gert J., Meijer, Chris J. L. M., Oudejans, Joost J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200818/
https://ncbi.nlm.nih.gov/pubmed/17916749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-085480
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