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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.

Several human inhibitor of apoptosis (IAP) family proteins function by directly inhibiting specific caspases in a mechanism that does not require IAP cleavage. In this study, however, we demonstrate that endogenous XIAP is cleaved into two fragments during apoptosis induced by the tumor necrosis fac...

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Bibliografische gegevens
Hoofdauteurs: Deveraux, Q L, Leo, E, Stennicke, H R, Welsh, K, Salvesen, G S, Reed, J C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171595/
https://ncbi.nlm.nih.gov/pubmed/10508158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.19.5242
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