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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.

Several human inhibitor of apoptosis (IAP) family proteins function by directly inhibiting specific caspases in a mechanism that does not require IAP cleavage. In this study, however, we demonstrate that endogenous XIAP is cleaved into two fragments during apoptosis induced by the tumor necrosis fac...

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Bibliografiset tiedot
Päätekijät: Deveraux, Q L, Leo, E, Stennicke, H R, Welsh, K, Salvesen, G S, Reed, J C
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1999
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171595/
https://ncbi.nlm.nih.gov/pubmed/10508158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.19.5242
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