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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.

The inhibitor of apoptosis (IAP) family of proteins are highly conserved through evolution. However, the mechanisms by which these proteins interfere with apoptotic cell death have been enigmatic. Recently, we showed that one of the human IAP family proteins, XIAP, can bind to and potently inhibit s...

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Detalles Bibliográficos
Autores principales: Roy, N, Deveraux, Q L, Takahashi, R, Salvesen, G S, Reed, J C
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170295/
https://ncbi.nlm.nih.gov/pubmed/9384571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.23.6914
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