A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC

BACKGROUND: Evasion of apoptosis contributes to the pathogenesis of solid tumours including non-small cell lung cancer (NSCLC). Malignant cells resist apoptosis through over-expression of inhibitor of apoptosis proteins (IAPs), such as X-linked IAP (XIAP). METHODS: A phenylurea-based small molecule...

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Main Authors: Dean, E J, Ward, T, Pinilla, C, Houghten, R, Welsh, K, Makin, G, Ranson, M, Dive, C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
Assuntos:
Translational Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813749/
https://ncbi.nlm.nih.gov/pubmed/19904270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605418
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