Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP

The inhibitor of apoptosis protein, XIAP, is frequently overexpressed in chemoresistant human tumours. An antisense oligonucleotide (AEG 35156/GEM 640) that targets XIAP has recently entered phase I trials in the UK. Method validation data are presented on three pharmacodynamic assays that will be u...

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Main Authors: Cummings, J, Ward, T H, LaCasse, E, Lefebvre, C, St-Jean, M, Durkin, J, Ranson, M, Dive, C
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2005
Ábhair:
Translational Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362094/
https://ncbi.nlm.nih.gov/pubmed/15685240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602363
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