Phase I/II Trial of AEG35156 X-Linked Inhibitor of Apoptosis Protein Antisense Oligonucleotide Combined With Idarubicin and Cytarabine in Patients With Relapsed or Primary Refractory Acute Myeloid Leukemia

PURPOSE: X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of caspases 3 and 9 which are overexpressed in acute myeloid leukemia (AML) and may contribute to chemoresistance. We report on a phase I/II trial of the XIAP antisense oligonucleotide AEG35156 in combination with reinduction ch...

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Vydáno v:J Clin Oncol
Hlavní autoři: Schimmer, Aaron D., Estey, Elihu H., Borthakur, Gautam, Carter, Bing Z., Schiller, Gary J., Tallman, Martin S., Altman, Jessica K., Karp, Judith E., Kassis, Jeannine, Hedley, David W., Brandwein, Joseph, Xu, Wei, Mak, Duncan H., LaCasse, Eric, Jacob, Christine, Morris, Stephen J., Jolivet, Jacques, Andreeff, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2009
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ORIGINAL REPORTS
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073380/
https://ncbi.nlm.nih.gov/pubmed/19652057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.21.8172
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