Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

We tested the effects of small-molecule XIAP antagonists based on a polyphenylurea pharmacophore on cultured acute myelogenous leukemia (AML) cell lines and primary patient samples. X-linked inhibitor of apoptosis protein (XIAP) antagonist N-[(5R)-6-[(anilinocarbonyl)amino]-5-((anilinocarbonyl){[(2R...

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Détails bibliographiques
Auteurs principaux: Carter, Bing Z., Gronda, Marcela, Wang, Zhiliang, Welsh, Kate, Pinilla, Clemencia, Andreeff, Michael, Schober, Wendy D., Nefzi, Adel, Pond, Gregory R., Mawji, Imtiaz A., Houghten, Richard A., Ostresh, John, Brandwein, Joseph, Minden, Mark D., Schuh, Andre C., Wells, Richard A., Messner, Hans, Chun, Kathy, Reed, John C., Schimmer, Aaron D.
Format: Artigo
Langue:Inglês
Publié: © 2005 by The American Society of Hematology 2005
Sujets:
Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895077/
https://ncbi.nlm.nih.gov/pubmed/15687241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3168
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