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Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans
Mutation in the prion gene PRNP accounts for 10–15% of human prion diseases. However, little is known about the mechanisms by which mutant prion proteins (PrPs) cause disease. Here we investigated the effects of 10 different pathogenic mutations on the conformation and ligand-binding activity of rec...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1863438/ https://ncbi.nlm.nih.gov/pubmed/17456603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610827104 |
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