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Ligand binding promotes prion protein aggregation – role of the octapeptide repeats
Aggregation of the normal cellular prion protein, PrP, is important in the pathogenesis of prion disease. PrP binds glycosaminoglycan (GAG) and divalent cations, such as Cu(2+) and Zn(2+). Here, we report our findings that GAG and Cu(2+) promote the aggregation of recombinant human PrP (rPrP). The n...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648294/ https://ncbi.nlm.nih.gov/pubmed/18959744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2008.06680.x |
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