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Aggregation of prion protein with insertion mutations is proportional to the number of inserts

Mutation in the prion gene, PRNP, accounts for approx. 10–15% of human prion diseases. However, little is known about the mechanisms by which a mutant prion protein (PrP) causes disease. We compared the biochemical properties of a wild-type human prion protein, rPrP(C) (recombinant wild-type PrP), w...

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Detalhes bibliográficos
Main Authors: Yu, Shuiliang, Yin, Shaoman, Li, Chaoyang, Wong, Poki, Chang, Binggong, Xiao, Fan, Kang, Shin-Chung, Yan, Huimin, Xiao, Gengfu, Tien, Po, Sy, Man-Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874237/
https://ncbi.nlm.nih.gov/pubmed/17187581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061592
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