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Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells

Recombinant prion protein, rPrP, binds DNA. Both the KKRPK motif and the octapeptide repeat region of rPrP are essential for maximal binding. rPrP with pathogenic insertional mutations binds more DNA than wild-type rPrP. DNA promotes the aggregation of rPrP and protects its N terminus from proteinas...

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Bibliografiske detaljer
Main Authors: Yin, Shaoman, Fan, Xingjun, Yu, Shuiliang, Li, Chaoyang, Sy, Man-Sun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533082/
https://ncbi.nlm.nih.gov/pubmed/18622017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800814200
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