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Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells

Recombinant prion protein, rPrP, binds DNA. Both the KKRPK motif and the octapeptide repeat region of rPrP are essential for maximal binding. rPrP with pathogenic insertional mutations binds more DNA than wild-type rPrP. DNA promotes the aggregation of rPrP and protects its N terminus from proteinas...

詳細記述

保存先:
書誌詳細
主要な著者: Yin, Shaoman, Fan, Xingjun, Yu, Shuiliang, Li, Chaoyang, Sy, Man-Sun
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533082/
https://ncbi.nlm.nih.gov/pubmed/18622017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800814200
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