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Morphine Induces Desensitization of Insulin Receptor Signaling

Morphine analgesia is mediated principally by the μ-opioid receptor (MOR). Since morphine and other opiates have been shown to influence glucose homeostasis, we investigated the hypothesis of direct cross talk between the MOR and the insulin receptor (IR) signaling cascades. We show that prolonged m...

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Autori principali: Li, Yu, Eitan, Shoshana, Wu, Jiong, Evans, Christopher J., Kieffer, Brigitte, Sun, Xiaojian, Polakiewicz, Roberto D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC180943/
https://ncbi.nlm.nih.gov/pubmed/12917346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.6255-6266.2003
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