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Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes

We recently reported that insulin and endothelin-1 (ET-1) can stimulate GLUT4 translocation via the heterotrimeric G protein Gαq/11 and through PI3-kinase–mediated pathways in 3T3-L1 adipocytes. Because both hormones stimulate glucose transport through a common downstream pathway, we determined whet...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Ishibashi, Ken-ichi, Imamura, Takeshi, Sharma, Prem M., Huang, Jie, Ugi, Satoshi, Olefsky, Jerrold M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2001
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC209278/
https://ncbi.nlm.nih.gov/pubmed/11342583
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