Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes

We recently reported that insulin and endothelin-1 (ET-1) can stimulate GLUT4 translocation via the heterotrimeric G protein Gαq/11 and through PI3-kinase–mediated pathways in 3T3-L1 adipocytes. Because both hormones stimulate glucose transport through a common downstream pathway, we determined whet...

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Pubblicato in:	J Clin Invest
Autori principali:	Ishibashi, Ken-ichi, Imamura, Takeshi, Sharma, Prem M., Huang, Jie, Ugi, Satoshi, Olefsky, Jerrold M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209278/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11342583/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11753
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