Evaluation of the Activities of Pyrimethamine Analogs against Plasmodium vivax and Plasmodium falciparum Dihydrofolate Reductase-Thymidylate Synthase Using In Vitro Enzyme Inhibition and Bacterial Complementation Assays

Pyrimethamine analogs were examined as potential agents against vivax malaria using a bacterial surrogate system carrying Plasmodium vivax dihydrofolate reductase-thymidylate synthase (PvDHFR-TS), in which the PvDHFR complemented chemically knocked out host dihydrofolate reductase. The system was in...

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Bibliographische Detailangaben
Hauptverfasser: Bunyarataphan, Sasinee , Leartsakulpanich, Ubolsree, Taweechai, Supannee, Tarnchompoo, Bongkoch, Kamchonwongpaisan, Sumalee, Yuthavong, Yongyuth
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635237/
https://ncbi.nlm.nih.gov/pubmed/16954316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00448-06
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