A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

The formation of polyglutamine-containing aggregates and inclusions are hallmarks of pathogenesis in Huntington's disease that can be recapitulated in model systems. Although the contribution of inclusions to pathogenesis is unclear, cell-based assays can be used to screen for chemical compound...

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Bibliografski detalji
Glavni autori: Apostol, Barbara L., Kazantsev, Alexsey, Raffioni, Simona, Illes, Katalin, Pallos, Judit, Bodai, Laszlo, Slepko, Natalia, Bear, James E., Gertler, Frank B., Hersch, Steven, Housman, David E., Marsh, J. Lawrence, Thompson, Leslie Michels
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2003
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC156307/
https://ncbi.nlm.nih.gov/pubmed/12730384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2628045100
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