A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

The formation of polyglutamine-containing aggregates and inclusions are hallmarks of pathogenesis in Huntington's disease that can be recapitulated in model systems. Although the contribution of inclusions to pathogenesis is unclear, cell-based assays can be used to screen for chemical compound...

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Bibliografische gegevens
Hoofdauteurs: Apostol, Barbara L., Kazantsev, Alexsey, Raffioni, Simona, Illes, Katalin, Pallos, Judit, Bodai, Laszlo, Slepko, Natalia, Bear, James E., Gertler, Frank B., Hersch, Steven, Housman, David E., Marsh, J. Lawrence, Thompson, Leslie Michels
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2003
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156307/
https://ncbi.nlm.nih.gov/pubmed/12730384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2628045100
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