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Pcaf Modulates Polyglutamine Pathology in a Drosophila Model of Huntington's Disease
Huntingtin peptides with elongated polyglutamine domains, the root causes of Huntington's disease, hinder histone acetylation, which leads to transcriptional dysregulation. However, the range of acetyltransferases interacting with mutant Huntingtin has not been systematically evaluated. We used...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
S. Karger AG
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304510/ https://ncbi.nlm.nih.gov/pubmed/21912091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000330505 |
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