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Pcaf Modulates Polyglutamine Pathology in a Drosophila Model of Huntington's Disease

Huntingtin peptides with elongated polyglutamine domains, the root causes of Huntington's disease, hinder histone acetylation, which leads to transcriptional dysregulation. However, the range of acetyltransferases interacting with mutant Huntingtin has not been systematically evaluated. We used...

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Bibliografische gegevens
Hoofdauteurs: Bodai, Laszlo, Pallos, Judit, Thompson, Leslie Michels, Marsh, J. Lawrence
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: S. Karger AG 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304510/
https://ncbi.nlm.nih.gov/pubmed/21912091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000330505
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