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Pcaf Modulates Polyglutamine Pathology in a Drosophila Model of Huntington's Disease
Huntingtin peptides with elongated polyglutamine domains, the root causes of Huntington's disease, hinder histone acetylation, which leads to transcriptional dysregulation. However, the range of acetyltransferases interacting with mutant Huntingtin has not been systematically evaluated. We used...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
S. Karger AG
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3304510/ https://ncbi.nlm.nih.gov/pubmed/21912091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000330505 |
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